In this study the hepatoprotective activity of the crude phenolic rich extract (CPRE) isolated from oyster mushrooms on carbon tetrachloride (CCl4)-induced oxidative stress was investigated in albino rats. The hepatoprotective activity was examined through various biochemical parameters. Administration of CCl4 for 28 days exhibited a significant increase (P<0.05) in serum markers of liver damage, i.e., alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, urea, creatinine, total lipids and triglycerides. Whereas, the serum markers were significantly decreased (P<0.05) by CPRE administration. CCl4 exposure significantly decreased (P<0.05) the hepatic antioxidant enzyme activities such as superoxide dismutase and glutathione peroxidase. Contrarily, the CPRE treatments showed significant increases (P<0.05) in these hepatic activities. The results obtained from this study clearly validated the potential antioxidant activity of CPRE isolated from oyster mushrooms against several oxidation systems in-vivo, which contributed to its hepatoprotective effects in CCl4-induced liver injury in male albino rats. Finally, oyster mushrooms could be added as an additional nutrient to food products as it constitutes a new potential source of natural antioxidant and antibacterial agents.
Osman, A., & Toliba, A. (2019). Hepatoprotective Effects of Crude Phenolic-rich Extract from Oyster Mushroom (Pleurotus ostreatus). Egyptian Journal of Food Science, 47(2), 157-164. doi: 10.21608/ejfs.2019.16213.1017
MLA
Ali Osman; Abbas Omar Toliba. "Hepatoprotective Effects of Crude Phenolic-rich Extract from Oyster Mushroom (Pleurotus ostreatus)", Egyptian Journal of Food Science, 47, 2, 2019, 157-164. doi: 10.21608/ejfs.2019.16213.1017
HARVARD
Osman, A., Toliba, A. (2019). 'Hepatoprotective Effects of Crude Phenolic-rich Extract from Oyster Mushroom (Pleurotus ostreatus)', Egyptian Journal of Food Science, 47(2), pp. 157-164. doi: 10.21608/ejfs.2019.16213.1017
VANCOUVER
Osman, A., Toliba, A. Hepatoprotective Effects of Crude Phenolic-rich Extract from Oyster Mushroom (Pleurotus ostreatus). Egyptian Journal of Food Science, 2019; 47(2): 157-164. doi: 10.21608/ejfs.2019.16213.1017